What do drug addicts, serial dieters and children from troubled homes have in common?
More than you might think.
Stress can play a pernicious role in triggering a vicious cycle that leaves these groups overwhelmed by uncontrollable impulses and distracted by negative feelings -- all of which may, in turn, spark subsequent cycles of relapse, bingeing and failure.
Through a career that spans almost three decades, Rajita Sinha, psychologist and head of the Yale Stress Center, has sought to understand the processes underlying these stress cycles in hopes they may one day be prevented.
The dance of human emotions
For Sinha, it all began with emotions.
She was 9 years old and living in her native India when she began training in classical Indian dance, which is heavily focused on experiencing and expressing emotions. Indian dancers use facial expressions and hand gestures to tell the stories of people's sacred lives.
"Dancing tied me to the powerful effects of our emotions," she recalls.
Sinha practiced the art form through college, growing ever more fascinated by how brain and physiology affect emotions and how emotions motivate behavior.
She started her career by working with individual emotions such as anger and sadness, examining how they affect the body and change our response to different stimuli in the environment. What she observed back then was that people don't generally have pure emotions -- that is, they don't feel just angry or fearful -- but that their emotions are often mixed.
"If you asked them how they were feeling, they would say they were stressed or upset," she says. She set out to understand how emotions work together, both to protect us and to cause the stress that can wear us down.
The habit of addiction
In 1994 Sinha was running the substance abuse treatment unit at Yale. As the clinical director, she was doing research on cognitive behavioral treatments that taught recovering addicts how to identify problems and overcome cravings.
Although the research showed that these skills worked, they tended to have only modest effects; a number of people benefited, but that number was not large.
"I would run these groups in my clinic and see the same individuals come back over and over again," Sinha recalls. "They would tell me, 'I know what I'm supposed to do, I have these skills, but when I'm out there and something happens, I just can't help myself.'"
"The biggest challenge with addiction, of course, is relapse, and I set out to understand what drives relapse; what brings these behaviors back."
It became clear that there was often a threshold moment during which some kind of a challenge or trigger prevented the recovering person from accessing his or her cognitive resources. The way the emotions were flooding the person somehow led to a greater risk of relapse.
In each case, Sinha observed that stress played a pivotal role in the loss of control. Clearly Sinha and her colleagues couldn't be out there with each person as he or she was relapsing, but they set out to replicate the behavior in a laboratory setting.
"We began to bring addicted people in recovery into the lab and gave them a series of challenges in controlled experiments. We found that when addicted individuals were under stress, they almost automatically wanted to start using drugs again."
The research began to establish a clear pattern of stress-induced craving for drugs -- both for those early in recovery and those who were actively using. And it wasn't just higher levels of anxiety and negative emotions that were making the recovering addicts seek relief from the stress; there was also a parallel process happening -- the stress was actually escalating the craving for the drug.
Subsequent experiments showed that stress played an important role in the loss of self-control across a spectrum of behaviors, including gambling and the consumption of tobacco, alcohol and food.
"We started to look into the brain to see what was happening and found that during those periods of arousal, the 'habit' regions in the brain were activated," Sinha says.
She and her colleagues spent a lot of time teasing apart this mechanism in an attempt to figure out how to break the cycle of addiction.
"We have lots of habits that are very important for survival. It's a very evolutionarily hard-wired response that comes from a primitive need to respond very quickly. It's very hard to break that link."
Drugs, food and habitual behaviors all have a direct effect on the biology of stress. It's a feed-forward model, Sinha observes. Her research has shown that stress begets more stress. This is of particular concern because there's a direct link between stress, anxiety, depression and chronic disease.