PORT CANAVERAL, Fla. -- On the eve of a possible U.S. Senate vote to make gay marriages unconstitutional, Rosie O'Donnell spoke out against the Bush administration's plans to ban same sex unions during a stop on a gay-friendly cruise, according to Local 6 News.

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Rosie Promotes Cruise, Discusses Possible Gay Marriage Ban

"I think this cruise comes at the perfect time, when they're considering an amendment making it illegal for us to have families," O'Donnell told Local 6 News partner Florida Today.

O'Donnell, who is a strong advocate of gay marriage and adoption, railed against President George W. Bush and the administration, according to the report.

"It will be the first time, except for prohibition, that bigotry has been added to the Constitution," O'Donnell said. "That the prevention of rights and exclusion of rights takes paramount over some religious ideology. And, supposedly, that is what we are fighting in Iraq -- A religious extreme government that is not letting people live freely."

The Norwegian Dawn cruise ship docked in Port Canaveral Tuesday with more than 2,000 passengers.

The seven-day trip departed New York on Sunday and is the first cruise of R Family Vacations, the O'Donnell-backed company that promotes family-friendly vacations for gay and lesbians.

Besides standard cruise ship entertainment fare, the 2,100 passengers on the chartered ship can attend discussion groups on adoption, artificial insemination, surrogacy and other topics of interest to gay parents or gay parents to be.

"It is not by any means only gay families (on the cruise)," O'Donnell said. "There are bi-racial families, one-parent families. There are heterosexual families. It's all families are welcomed. It is, in my opinion, what America is all about."

O'Donnell will receive the key to Key West when her cruise stops at the popular island, according to Local 6 News.

Watch Local 6 News for more on this story.