It's a medical mystery right here in Central Florida.
Brianna Skriver was a healthy, vibrant 5-year-old girl who is now confined to a wheelchair, and doctors have no idea why.
For the past five years, Brianna, 10, has been in and out of Duke Medical Center and Johns Hopkins.
Each year, thousands of people apply to the National Institutes of Health's Undiagnosed Diseases Program and Brianna was one of a rare few accepted.
Doctors have now tested Brianna for every known condition, but no one can say what's causing her to stop walking, talking, even eating.
She now spends most of her days coloring with her best bud, black Lab Ollie, by her side. But that's not how it used to be.
"My daughter was not born this way," said Brianna's mom, Tammy Skriver.
Brianna used to be a soccer player, dancer and loved to play outside.
Tammy says that all changed after Brianna got immunized for kindergarten.
"I started noticing on the soccer field that she was falling a lot and her run was becoming different," said Tammy.
Then, Brianna's teacher called to tell Tammy that her daughter was out of control. The pediatrician agreed and prescribed Brianna ADHD medication.
"That day will forever remain in my mind for the rest of my life," said Tammy. "Brianna went from 100 miles an hour to 500 miles an hour."
Concerned that Brianna may have overdosed, Tammy called the doctor who told her to stick with it and that it'll get better in a few months.
"At that point, Brianna was a vegetable on the couch, drooling, wetting herself," said Tammy.
And Brianna's doctor was stumped. So Tammy drove Brianna across the country to renowned experts. They did blood tests, spinal taps, MRIs, CAT scans and PET scans. Brianna still has scars from skin and muscle biopsies, she even had a brain biopsy.
"Everything has come back either normal or negative," said Tammy.
After five years of trying traditional medicine, the Skrivers are now turning to Winter Park's Dr. Joya Shoen.
Dr. Shoen says an alternative IV treatment with antioxidants could detox Brianna's cells and improve her condition. They hope to start the IV in a few weeks.
"Autism and many other conditions have been reversed with her protocol," said Dr. Shoen.
To get ready, Brianna is on an all natural diet, pureed and administered through her feeding tube every 30 minutes. It's a painstaking process that her mom hopes will eventually cure her little girl.
"I just want my daughter healthy, I'm not going to give up," said Tammy.
Since Brianna has reached her Blue Shield insurance cap, she is now on Medicaid, which will not cover the $25,000 IV treatment. Her friends have developed the website, www.friendsofbrianna.com to raise money.