December 2001 - De Klerk's first wife, Marike, is murdered. A security guard is later convicted of her murder.
2004 - Serves on the South African delegation that helps South Africa land the 2010 Soccer World Cup.
June 2006 - Hospitalized for respiratory complications after colon cancer surgery.
May 2012 - In an interview with CNN's Christiane Amanpour, de Klerk said he disapproves of the effects of apartheid, but not the concept of a 'separate but equal' nation state. Later, de Klerk clarified his position calling apartheid "morally unjustifiable".