A chain reaction crash on State Road 429 temporarily blocked traffic in Winter Garden Monday afternoon, officials with the Florida Highway Patrol said.
The crash involving four cars was reported at 3:15 p.m. at mile marker 19 when one car rammed into another creating a reaction crash, according to the FHP.
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All vehicles were in the southbound lanes. The lanes reopened by 5:50 p.m., troopers said.
Two patients were airflighted to Orlando Regional Medical Center, including one person in critical condition.
Two other crash victims were taken by ambulance to a hospital in stable condition.
Troopers said all injuries appear to be non life threatening.
The crash remains under investigation.