Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis.

Indiana tied a program record Saturday by earning its sixth Big Ten win of the season, joining the 1967 and 1987 teams. Tuttle also lost a fumble that led to a Wisconsin field goal. “He goes running into the locker so I’m thinking, I’m telling Dex (Dexter Williams), ‘OK, this is your time. Indiana entered the day with a Big Ten-leading 18 takeaways and used an early turnover to take the lead for good. Wisconsin had moved the ball to the Indiana 39 when Tiawan Mullen sacked Mertz and knocked the ball loose.