Jamaal Williams ran for his 14th touchdown to help the Detroit Lions get off to a strong start and they didn't slow down in a 40-14 rout of the Jacksonville Jaguars on Sunday.

Jaguars return specialist Jamal Agnew is inactive for Jacksonville’s game against the Denver Broncos at Wembley Stadium.

Justin Herbert threw for three touchdowns, Austin Ekeler rushed for 117 yards and scored twice and the Los Angeles Chargers knocked the Las Vegas Raiders from the unbeaten ranks with a 28-14 victory.