Christian McCaffrey became the fourth-fastest player in the Super Bowl era with 100 career touchdowns, Brock Purdy played a near-perfect game and the San Francisco 49ers overwhelmed the Miami Dolphins 35-13.

Los Angeles Rams wide receiver Puka Nacua is questionable to play Monday night against the New York Giants because of a groin injury.

After spending time during training camp trying to manage Myles Garrett’s knee injury, it was the Los Angeles Rams’ dismal season-opening loss to the San Francisco 49ers that made it evident to everyone that the star defensive end needed surgery.

San Francisco 49ers coach Kyle Shanahan signed a contract extension this offseason that will keep him with the team for the long term.

In the nearly seven months since the San Francisco 49ers last played a game that counted, they watched the Seattle Seahawks celebrate a Super Bowl win in the Niners’ home locker room and the Los Angeles Rams get all the hype after an offseason that featured the addition of Myles Garrett.

Mike Evans, Demarcus Robinson and Deebo Samuel caught touchdown passes from Brock Purdy, and the San Francisco 49ers routed the Los Angeles Rams 27-7 in the first NFL regular-season game in Australia.

The San Francisco 49ers have arrived in Australia, mostly gotten over the impact of the long flight and now are getting prepared to open their season on Friday in Melbourne against the Los Angeles Rams.

The San Francisco 49ers have arrived in Melbourne for their season-opening NFL game against the Los Angeles Rams at the Melbourne Cricket Ground on Sept. 11.

The San Francisco 49ers are set for the longest road trip in NFL history.

The San Francisco 49ers started their final set of practices before leaving to play the season opener in Australia with defensive end Nick Bosa still sidelined and tight end George Kittle ramping up to play.

Las Vegas rookie quarterback Fernando Mendoza saw what it was like Thursday night to face a strong NFL pass rush even against a San Francisco defense comprised of reserves.

Commissioner Roger Goodell says the NFL is looking into whether San Francisco 49ers owner Jed York will be punished for violating the league’s personal conduct policy after he was caught in a prostitution sting in Ohio.

San Francisco 49ers owner Jed York was arrested over the weekend in Ohio and pleaded no contest to misdemeanor charges of disorderly conduct and possessing criminal tools.

San Francisco 49ers star tight end George Kittle was taken off the physically unable to perform list, providing hope that he might be able to return from a ruptured right Achilles tendon before the season opener.

The San Francisco 49ers are bringing back former All-Pro Deebo Samuel for a second stint after starting receiver Ricky Pearsall got sidelined by a knee injury.

Police are searching for suspects after a weekend break-in at the home of Philadelphia Eagles running back Saquon Barkley.

The Santa Clara County District Attorney’s Office has issued an arrest warrant for San Francisco 49ers receiver Brandon Aiyuk on a misdemeanor charge of exhibition of speeding.

The San Francisco 49ers will bookend the NFL’s largest ever international slate by playing the 2026 season opener in Melbourne against the NFC West rival Los Angeles Rams and facing the Minnesota Vikings in Week 11 in Mexico City.

The San Francisco 49ers and star left tackle Trent Williams have agreed to a two-year, $50 million contract that gives the team clarity about the future of one of its most important players before the NFL draft.

Tom Brady and the Fanatics Flag Football Classic are moving closer to home for their inaugural event, switching from Saudi Arabia to Los Angeles.

The Seattle Seahawks are expected to hire San Francisco 49ers tight ends coach and run game coordinator Brian Fleury as their new offensive coordinator, a person with knowledge of the hiring process said Sunday.

The San Francisco 49ers will be the team facing the division-rival Los Angeles Rams in the first-ever regular-season NFL game in Australia next season, and the Dallas Cowboys will be one of the teams playing the first game in Rio de Janeiro, the league said Thursday.

The Tennessee Titans have agreed to hire Robert Saleh as their coach, hoping he can speed up their rebuild and end the franchise’s skid of four straight losing seasons.

Seattle Seahawks quarterback Sam Darnold has a left oblique injury.

San Francisco's star linebacker Fred Warner is out for the 49ers' playoff game against Seattle.

The Philadelphia Eagles are moving on from offensive coordinator Kevin Patullo.

Brock Purdy threw a 4-yard touchdown pass to Christian McCaffrey, leading San Francisco to a 23-19 victory over defending Super Bowl champion Philadelphia in a wild-card game.

San Francisco 49ers tight end George Kittle tore his right Achilles tendon late in the first half of a victory in a wild-card playoff game at Philadelphia.

San Francisco's offense had been nearly unstoppable heading into a showdown with Seattle with the No. 1 seed in the NFC at stake.

The Seattle Seahawks have secured the No. 1 seed in the NFC playoffs.

Brock Purdy threw a 38-yard touchdown pass to Jauan Jennings with 2:15 to play, and the San Francisco 49ers forced an incomplete pass on the final play from the 2 to beat the Chicago Bears 42-38 and set up a Week 18 showdown for the top seed in the NFC.

The Seattle Seahawks are closing in on the NFC West title after a 27-10 win over the Carolina Panthers.

Quarterback Philip Rivers came out of retirement to lead the Indianapolis Colts to the playoffs.

Carolina Panthers safety Tre’von Moehrig has been suspended one game without pay for punching San Francisco 49ers wide receiver Jauan Jennings in the groin during Monday’s game.

Christian McCaffrey had a big night in his first game against Carolina since the Panthers traded him to San Francisco three years ago.

San Francisco 49ers receiver Brandon Aiyuk has had the guaranteed money in his contract for next season voided.

Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22.

The NFL trade market has become more active in recent years.

The San Francisco 49ers have activated star tight end George Kittle from injured reserve.

Quarterback Brock Purdy has been ruled out for his third straight game for the San Francisco 49ers due to a toe injury.

The Tampa Bay Buccaneers keep losing key players and stockpiling wins.

Baker Mayfield’s heroics came early in the fourth quarter instead of the final minutes.

Eddy Piñeiro hit a 41-yard field goal in overtime before San Francisco stopped Kyren Williams on fourth down with 3:36 to play, and the short-handed 49ers hung on for a thrilling 26-23 victory over the Los Angeles Rams.

Parker Washington has scored Jacksonville's first punt return touchdown in eight seasons, leading the Jaguars to a 26-21 victory over the San Francisco 49ers.

San Francisco 49ers quarterback Brock Purdy is dealing with a toe injury and is considered "week to week."

San Francisco 49ers quarterback Brock Purdy is a "long shot" to play against the New Orleans Saints on Sunday due to a toe injury.

San Francisco 49ers star Christian McCaffrey is questionable for the season opener after injuring his calf at practice.

President Donald Trump, the NFL and scores of stars in the entertainment and sports worlds have reacted to Taylor Swift and Travis Kelce's engagement.

The San Francisco 49ers have acquired running back Brian Robinson from the Washington Commanders for a 2026 sixth-round draft pick.

Soho House plans to go private again after four years on Wall Street.

The NFL is continuing its on-field social justice messaging for a sixth straight season.

The San Francisco 49ers have brought back Robert Saleh as defensive coordinator to revive their struggling defense.

Dallas Cowboys guard Rob Jones says he broke a bone in his neck during the first padded practice of training camp and is expected to miss two to three months.

The NFL often sees last-place teams bounce back to win their division, with 25 teams achieving this since 2002.

The San Francisco 49ers have agreed on a deal to acquire Bryce Huff from Philadelphia after the pass rusher restructured his contract with the Eagles.

Scottish soccer club Rangers has confirmed a U.S.-based consortium that includes an investment arm of the San Francisco 49ers has purchased a majority ownership stake.

The Indianapolis Colts have apologized to Miami Dolphins receiver Tyreek Hill and Microsoft for a video released on social media during the NFL schedule release.

George Kittle agreed to a four-year contract extension with the San Francisco 49ers that will make him the highest-paid tight end in NFL history.

San Francisco 49ers general manager John Lynch often feels as though he’s entered a strange new scouting universe when he interviews an NFL draft prospect.

Star tight end Trey McBride has agreed to a four-year deal with the Arizona Cardinals as the franchise locks up one of the NFL’s best young players through the 2029 season.

The Minnesota Vikings acquired restricted free agent running back Jordan Mason from the San Francisco 49ers and rewarded him with a two-year deal worth up to $12 million.

Fullback Kyle Juszczyk is returning to the San Francisco 49ers on a two-year, $8 million contract just days after being cut, according to a person familiar with the deal.

The opening of free agency for the San Francisco 49ers was more about their losses than their additions.

A person with knowledge of the trade tells The Associated Press the Washington Commanders have acquired wide receiver Deebo Samuel from the San Francisco 49ers, pending a physical, for a fifth-round pick.

The San Francisco 49ers have given receiver Deebo Samuel permission to seek a trade, according to a person familiar with the situation.

The Miami Dolphins will play in the NFL’s first-ever regular-season game in Spain when Madrid hosts a matchup next season at iconic Bernabéu Stadium.

The San Francisco 49ers fired special teams coach Brian Schneider following a season when repeated blunders in the kicking contributed to a losing season, a person familiar with the decision told The Associated Press.

Tyreek Hill has not shied away from accountability during one of the least productive seasons of his nine-year career.

Tua Tagovailoa threw for 215 yards and a touchdown, Jason Sanders nailed five field goals, and the Miami Dolphins kept their playoff chances alive by beating the San Francisco 49ers 29-17 on Sunday.

The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.

Pro Football Hall of Fame wide receiver Randy Moss says he is being treated for cancer and is recovering from major surgery.

Joshua Karty kicked four field goals and the Los Angeles Rams survived a slugfest a week after winning a shootout, beating the San Francisco 49ers 12-6 in a key game in the NFC West race.

San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season.

Hall of Fame wide receiver Randy Moss revealed he’s dealing with a health issue and asked fans to pray for him and his family.

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills clinched their fifth straight AFC East title with a 35-10 victory over the San Francisco 49ers on a snowy Sunday night.

San Francisco 49ers quarterback Brock Purdy will miss Sunday’s game against the Green Bay Packers with a sore throwing shoulder.

Two of the new holiday movies coming to TV this season have a Taylor Swift connection that her fans would have no problem decoding.

San Francisco 49ers quarterback Brock Purdy has been limited in practice this week because of a sore throwing shoulder and will likely be a game-time decision for Sunday’s game at Green Bay.

Nearly two decades ago, My Chemical Romance released their career-defining rock opera, “The Black Parade.”

Jake Moody redeemed himself after missing three earlier field goals by booting a 44-yarder as time expired to give the San Francisco 49ers a 23-20 victory over the Tampa Bay Buccaneers in running back Christian McCaffrey’s season debut.

A person familiar with the matter says San Francisco 49ers star defensive end Nick Bosa has been fined by the NFL for wearing a hat with a pro-Donald Trump message during a postgame television interview.

San Francisco 49ers All-Pro running back Christian McCaffrey has looked good in his first week back at practice after being sidelined by Achilles tendinitis and is on track to make his season debut Sunday against Tampa Bay.

Dallas Cowboys owner Jerry Jones says quarterback Dak Prescott is likely to miss at least four games with a move to injured reserve because of his strained hamstring.

Running back Ezekiel Elliott is inactive as expected for Dallas at the Atlanta Falcons, leaving Rico Dowdle and Dalvin Cook to lead the struggling ground game as the Cowboys look to end a two-game losing streak.

The Minnesota Vikings have agreed to acquire eight-year veteran left tackle Cam Robinson from the Jacksonville Jaguars, according to a person with knowledge of the trade.

The 1-year-old daughter of San Francisco 49ers cornerback Charvarius Ward has died after battling heart problems since her birth.

Brock Purdy threw a touchdown pass and ran for another score to send the San Francisco 49ers into their bye week on a high note with a 30-24 victory over the Dallas Cowboys.

San Francisco 49ers star receiver Deebo Samuel has been released from the hospital after being treated for a bout of pneumonia.

San Francisco 49ers star receiver Brandon Aiyuk will miss the rest of the season after tearing ligaments in his right knee.

Patrick Mahomes overcame two interceptions to deliver a few big plays with his feet and the Kansas City Chiefs remained the league’s only undefeated team after beating the San Francisco 49ers 28-18 in a Super Bowl rematch.

San Francisco 49ers rookie receiver Ricky Pearsall will be activated and make his NFL debut against Kansas City 50 days after he was shot in the chest.

Eight months later, the pain of losing a second Super Bowl in five seasons to the Kansas City Chiefs has barely subsided for the San Francisco 49ers as they prepare for a rare regular season rematch.

San Francisco 49ers rookie receiver Ricky Pearsall returned to the field for practice for the first time since he was shot in the chest during an attempted robbery nine days before the season opener.

San Francisco 49ers rookie receiver Ricky Pearsall is set to return to practice next week for the first time since he was shot in the chest in a robbery attempt nine days before the season opener.

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the Cardinals’ 24-23 victory over the San Francisco 49ers on Sunday.

The New York Jets have activated third-string quarterback Adrian Martinez for Sunday’s game against the Minnesota Vikings at Tottenham Hotspur Stadium.

San Francisco 49ers All-Pro running back Christian McCaffrey has traveled to Germany to consult with a specialist about his Achilles tendinitis.

Joshua Karty hit a 37-yard field goal with 2 seconds to play, and the Los Angeles Rams staged a spectacular late rally for a 27-24 victory over the San Francisco 49ers.

Sam Darnold passed for 268 yards and two touchdowns against his former team, including a 97-yard strike in the second quarter to Justin Jefferson, and an attacking defense again fueled the Minnesota Vikings in a 23-17 victory over the San Francisco 49ers.

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf and Achilles tendon injuries.